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CasNo： 1093861-60-9
MF： C26H17ClF9N3O3
Afoxolaner (NexGard®) is used to treat and prevent flea and tick infestations in dogs. It is also used as a preventive for Lyme disease. After being ingested by a dog, afoxolaner is distributed throughout the dog's body. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal.
The invention relates to a preparation m...
The invention relates to synthesis of ar...
Disclosed are compounds of Formula 1, wh...
Disclosed is a method for preparing a co...
![4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]naphthalene-1-carboxylic acid](/upload/2024/11/bfe023f9-b11b-42f5-b2c6-2c639ba63592.png)
4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]naphthalene-1-carboxylic acid
1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane hydrochloride
![4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide](/upload/2024/11/171125dc-37ff-42cf-802c-44606cde24c5.png)
4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
| Conditions | Yield |
|---|---|
|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.666667h; pH=10;
|
77% |
4-(5-(3-chloro-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1-naphthalenecarbonitrile
2-ammonia-N-(2,2,2-trifluoroethyl)acetamide
4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
| Conditions | Yield |
|---|---|
|
With hydroxylamine hydrochloride; zinc trifluoromethanesulfonate; In 5,5-dimethyl-1,3-cyclohexadiene; water; at 110 ℃; for 8h; Sealed tube;
|
81.4% |
4-[3-[3-chloro-5-(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-oxo-2-buten-1-yl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalenecarboxamide
1-oxo-1-N-(2,2,2-trifluoroethyl)-1,2-diaminoethane hydrochloride
4-bromonaphthalene-1-carboxylic acid
2-ammonia-N-(2,2,2-trifluoroethyl)acetamide
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