What is the 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide?

4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide is , while it's Molecular Formula is C 22 H 17 Cl 2 F 6 N 3 O 3 . Fluralaner is a novel systemically administered insecticidal and acaricidal compound that provides long-acting efficacy after oral administration to dogs. Fluralaner belongs to a new class of compounds, the isoxazolines. A field study has shown that a single fluralaner dose administered orally to dogs provides at least twelve weeks of flea- and tick-control. The long duration of activity offers a more convenient treatment over monthly flea and tick control treatments with a potential compliance advantage, reducing the risk of vector-transmitted diseases.

What is the CAS number for 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide?

The CAS number of 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide is 864731-61-3.

What is 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide (864731-61-3) used for?

Fluralaner (INN) is a systemic insecticide and acaricide that is administered orally. The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014. The EU approved the drug in February 2014. Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.

Fluralaner

Basic information

Product Name:Fluralaner
CasNo.:864731-61-3
MF:
MW:556.292

Physical and Chemical Properties

Purity:99%
Boiling Point:
Packing:
Throughput:

Inquiry

Product Details

CasNo： 864731-61-3

Factory Supply High Purity 99% Veterinary API 864731-61-3 99% Fluralaner powder in Stock

Molecular Formula:C₂₂H₁₇Cl₂F₆N₃O₃
Molecular Weight:556.292
PKA:12.50±0.46(Predicted)
Density:1.51±0.1 g/cm3(Predicted)

864731-61-3 API Fluralaner powder Usage and manufacuturer

Fluralaner, (INN) sold under the brand name Bravecto among others, is a systemic insecticide and acaricide that is administered orally or topically. Fluralaner is distributed throughout a pet's body after administration. When a flea or tick bites the pet, it's exposed to the drug and killed during its blood meal. Fluralaner is generally safe for dogs, but it's toxic for fleas and ticks. It's not licensed for use in humans. Liaoning Pharmaceutical Innovation Co.,Ltd. originated from Tianjin Pharmaceutical Innovation Co.,Ltd. which was established in July 2009 and is located in Tianjin Binhai Development Zone. It is a national high-tech enterprise specializing in the development, research and production of raw materials and intermediate processes, and providing pharmaceutical R&D outsourcing services. Our company's main business covers all over the world. We have 47 patents including 6 authorized invention patents . The company has been recognized as a national high-tech enterprise and has established a quality management system with ISO9000 and ICHQ7 as the core, ISO14001 international environmental management certification system and OHSAS18001 occupational health management system.

864731-61-3 Relevant articles

Synthetic method of fluralana

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, (2022/04/15)

According to the method, 2-methyl-5-brom...

PROCESS FOR PREPARATION OF ISOXAZOLINE SUBSTITUTED BENZAMIDE COMPOUND

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, (2022/03/14)

The invention relates to process for the...

PROCESS FOR PREPARING FLURALANER

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Paragraph 0074-0082, (2021/06/26)

The invention relates to an improved pro...

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Paragraph 0173-0175; 0182-0189, (2021/12/07)

The invention discloses a fluororesonide...

864731-61-3 Process route

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: C₁₃H₁₃ClF₃N₃O₃

: 864731-61-3
A₁₄₄₃

Conditions

Conditions	Yield
With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 14h;	92.1%
With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃;	91.8%
for 3h;	83%

: 2-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methylbenzoyl]amino]acetic acid

: 753-90-2
trifluoroethylamine

: 864731-61-3
A₁₄₄₃

Conditions

Conditions	Yield
2-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methylbenzoyl]amino]acetic acid; trifluoroethylamine; With dmap; In dichloromethane; at 20 - 25 ℃; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Reagent/catalyst;	75.5%
2-[[4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methylbenzoyl]amino]acetic acid; With N-[3-(diethylamino)propyl]-N'-ethylcarbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.25h; trifluoroethylamine; With dmap; In dichloromethane; at 20 ℃; for 2h;

864731-61-3 Upstream products

753-90-2
trifluoroethylamine
201230-82-2
carbon monoxide
359821-38-8
2-ammonia-N-(2,2,2-trifluoroethyl)acetamide
864725-62-2
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

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